No rashes, no itching, barely any yellowing of anything except something that should be white. The drug can cause a rapid increase in both your metabolic rate and body temperature. JavaScript is disabled. I have tried essentially all of the most popular protocols with DNP. Just remember, youre going to have to keep your expectations lower. Kristina Donnay, medical director at Maricopa Wellness Center. If somebody was going to die of obesity because they literally couldn't exercise and were absurdly overweight, then I believe DNP could then have some sort of potential therapeutic application. Bright yellow piss will kick in. Many companies selling DNP are based in the United States and ship packages illegally in a way that makes them unlikely to be seized by border control agents in other countries. DMA can be produced by reacting ammonia with urea, which produces ammonium carbamate (NH4OCA) from carbonyl groups of amino acids. He also had an extremely high body temperature, his liver was failing, and he was struggling with whats referred to as metabolic acidosis. I do believe the future is going to uncover some interesting things about DNP though, and perhaps other analogs with similar attributes. Yea time to bump it up and feel the burn..lol. These shocking truths reveal that dinitrophenol is incredibly dangerous, and that even people who seek medical help very soon after noticing adverse side effects may not have a chance to survive. Dieters who restrict their food intake are more likely to maintain their losses than those who continue eating normally (9). Dinitrophenol was then used for a number of other industrial things such as dying or preserving wood, acting as a herbicide, and helping to develop photographs. Dinitrophenol basically impairs the way that your cellular respiration process works, meaning that it interferes with the way that your cells breathe. Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): Evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users. Losing weight without dieting is, however, the slimmers (and the physicians) dream. 2,4-dintrophenol (DNP) helps to move protons across membranes in cells, resulting in a reduction in the production of ATP (adenosine triphosphate, the molecule that transports energy within cells). Some of these include: The DNP molecule is a fat-burning agent and it increases the production of heat by burning fat cells. It aims to provide reliable information on their safe administration, side effects and dangers. What is the DNP drug? It has been illegally sold as a diet pill for weight loss. But no matter what its called, its not fit for human consumption. BBC News Warning over illegal weight loss chemical DNP, 3. What You Could Use Instead of DNP for Weight Loss? Starting weight 16st 6lb. These effects occur rapidly (over several hours) and may present a significant risk of death. He was only 22. Upon a first glance, it sounds incredible and like it is the most unbeatable fat burning compound in existence and you can supposedly eat like crap on it and still get ripped. 2 4 dinitrophenol, also known as dinitrophenol or simply DNP (slang terms include Dinitro, Nitrophen, and Dnoc) is a very powerful substance that many people have been using as a weight loss substance. Added weights back when my back injury healed enough to allow it. Among the things that people are doing to lose weight (aside from the obvious exercise) include taking a number of different supplements, both natural and otherwise. As far as a fat burner, it works, there's no denying that. If youre looking for a substance thats going to help you lose weight as fast as DNP, then, unfortunately, youre out of luck. DNP has some painful results, so do not jump for DNP out of curiosity, or without the needed will power to operate this . Jumping back into a surplus and getting off the DNP always seemed to result in a favorable anabolic rebound effect where I could then continue to gain muscle with a more favorable ratio of muscle:fat once again. 2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. He was only 22. In the case of Eloise Perry reported by the BBC, the sellers shipped DNP into the United Kingdom from China using oil drums. Zero alcohol. This can lead to serious side effects such as organ failure. My dnp cycle results. Weight: 211.20. weight loss after 12 months and a 6.77% weight loss after 24 months (95% CI [8.68, 6.90] and [8.78, 4.76], respectively). Four deaths in the UK and up to 60 worldwide have recently been attributed to the substance 2,4-dinitrophenol (DNP), an industrial chemical that has become popular among people wanting to lose weight, including bodybuilders and people with eating disorders. Best Fat Burner For Men in 2023 - That Works Specifically For Him? Acetyl-L-Carnitine - 500mg's three times a day. ). Not only that, but I have noticed that even when I stick to my guns and endure the torture of being starving all day while on DNP in the single digit levels of body fat %, I dont lose fat that easily, or much at all. 1 Although DNP was known at the time to be highly effective in the manufacturing of . DNP is highly toxic, and people working with or around the substance can develop side effects like weight loss, high fever, and death. Dinitrophenol (DNP) fatality associated with a falsely elevated salicylate level: A case report with verification of laboratory cross reactivity. [Thought this might be a useful datapoint for people if/when DNP ever approaches mainstream use, but feel free to delete if we don't want to encourage people to use DNP long-term. Introduction: My name is Mrs. Angelic Larkin, I am a cute, charming, funny, determined, inexpensive, joyous, cheerful person who loves writing and wants to share my knowledge and understanding with you. Side effects: none. The 7-day DNP fat loss plan involves a moderate to high dosage of DNP for fat burning. See additional information. DNP is a chemical uncoupling agent, which is interesting. 5 Feel-Good Exercises to Help with Stress, The Best Fasting Diet for Weight Loss in 2023, Marginal gains theory: how to make small improvements in your weight loss journey, 10 Healthy things to include in your Easter stuffer basket. When I overate on DNP to test this, I still gained fat. As a result, body reserves of fat and carbohydrate are mobilised and weight is lost. Try to avoid any drug or supplement that claims it can cause weight loss without the need for dietary changes or increased exercise. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Pros of getting a DNP A DNP can qualify you for more advanced positions, including director- and executive-level roles in hospitals and health care advocacy organizations. The problems started in the 1930s, when 2,4-dinitrophenol (DNP) became one of the first chemicals used for weight loss. At this point, I would still be eating enough calories and not doing such an insane amount of cardio that a heightened appetite would not be a huge detriment to my progress because it wont be that difficult to stick to my caloric allotment, and fat will melt off when I'm over 10% body fat while on DNP. In the early hours of the morning on 12 April 2015, 21-year-old student Eloise Parry swallowed eight capsules of weight loss pill 'DNP'. I'd like to see what 6% feels like. We avoid using tertiary references. 1,2 First discovered by factory workers who accidentally consumed the compound on the job, they experienced an unexpected result of quick weight loss. As a fat burning agent, I wouldn't advise using DNP. By increasing the amount of heat that our cells produce, dinitrophenol works in a process known as uncoupling. In this article, weve outlined the reasons that people use DNP, and also the reasons that you should not use it if you value your health and longevity. This is where I came to the conclusion that for me personally, the only time DNP use would make sense would be when I'm in the double digit range of body fat % and am trying to cut down to the single digits. 10 best food and drink to help you get better sleep. "DNP (2,4 dinitrophenol) The first weight loss drug ever offered to the public, around 1933. According to the FDA, in 2003, one online seller was sentenced to 5 years in prison after one of his customers died from DNP use. TRT shots AM or PM? Liked by Dr. What Are Good Diet Pills? Dubbed the steroid guru, Duchaine was notorious as a promoter of steroids for bodybuilding. In theory, by cycling this method each time body fat levels get to an unreasonable level, one could essentially be on a perma-bulk where they are constantly gaining muscle at a favorable ratio relative to their gains in body fat. (415) 600-5760. Maricopa Wellness Center's medical director, Dr. Kristina Donnay, DNP, FNP-C, gets many emails asking aesthetic and wellness questions. I had a lot of the stuff on hand and was going to use some of it to help with weight loss. Gets less effective the leaner you get ime. The mitochondrial uncoupler 2,4-dinitrophenol (DNP) shows proof-of-principle that mitochondrial protonophores have weight-loss effects in humans as ~90% of patients taking 300 mg DNP per day (3 mg . Also helped me sleep better at night. That certainly wasnt enough to stop people from using it, though. He also had an extremely high body temperature, his liver was failing, and he was struggling with whats referred to as metabolic acidosis. I was flat all the time, it was extremely difficult to get a good workout in. The more efficient use of oxygen helps you lose weight quickly because there is less stored fat on your body compared to when youre eating healthy foods that are full of carbs and fats. The reason that dinitrophenol is so dangerous (and the reason that people began using DNP weight loss supplements) is a result of the way that the substance affects our cells. lets get this figured out. The same . MISTAKES: It could be that the purpose of your life is only to serve as a warning to others. This heat helps in maintaining body temperature and it also helps with weight loss. Related articles:Perimenopause Supplements for Effective Weight ManagementRelated articles:Foods to Avoid for Fat Loss: A Holistic Approach to Sustainable Weight Management DNP Dosage and Regimes for Optimal Use The typical DNP cycle was 7-8 days on, followed by 7-8 days off. One such substance is the DNP drug, or 2-4 dinitrophenol, a compound that many people have been using for weight loss despite the fact that others have been injured and even died from using it. Low carb diets have shown time and time again to be an effective weight loss agent. The human body is simply not supposed to shed weight that quickly except under extreme, and usually unhealthy, circumstances. Holborow A, et al. This can lead to cardiac arrest and coma. R-ALA - 100mg's three times a day w/ meals. After being injected, it increases the metabolism an average of 30% over baseline in less than a minute, returning back to normal anywhere from 6 to 48 hours. the fatal allure of slimming drugs. DNP (2,4-dinitrophenol) is a highly toxic chemical that can cause severe and potentially life-threatening side effects, including hyperthermia, organ damage, and death. Social media also makes it easier for sellers to target potential buyers. Brothers stay strong and survive these days. These observations led Maurice Tainter and Windsor Cutting at Stanford University to study the effects of DNP and in 1933 they reported that metabolism was stimulated by 50% in patients taking the chemical. Conclusion. If youre a woman, it may be that your age and weight are the largest factors affecting your chances of success. With that being said, insulin resistance can be reversed with far safer alternatives. what is diet? Molly can be a pill, capsule, or powder. Why is the DNP drug unsafe? This was my third run, the previous two having been 2 weeks each when I was at a much lower weight. . Bleasdale EE, et al. Dinitrophenol was marketed as a weight loss supplement in 1933, in an astounding example of how researchers are not necessarily working in the interest of the general public. caused an explosion in the popularity of DNP as a weight-loss drug. PhenQ Vs. Leanbean: which is best for weight loss? 2 grams Vitamin C divided into 2 doses. One such individual was hospitalized about 16 hours after taking what is believed to be DNP with an extremely high body temperature of 102 degrees Fahrenheit. i wanna lose the maximum amount of bf before i start my cycle. Weight: 208.80. Conclusion. Drinking water can help reduce appetite and make you burn more calories. This happened when the FDA first caught on to the dangerous nature of the substance in 1938. While some individuals feel that they absolutely need some carbs in their diet while on DNP to function, I actually found that using a Ketogenic, or very low carb style diet is the most comfortable way to diet on DNP (I've tried high-carb, moderate-carb, low-carb, and Keto). what is training schedule? Since our cells are busy producing heat, this means that theyre using valuable energy that should be directed towards other functions like the respiration of ATP, the most valuable source of energy that our bodies use. However, it can be used safely by those who follow the directions on their product label carefully and take care not to exceed recommended doses over time (which may include up to 4 grams per day). Would you use it with a seal of approval? Supplements: multivitamin, taurine, Vitamin C, L-carnitine, B12, and NAD. Lets Find Out. (2018). The above things have led to some people referring to dinitrophenol as the worlds deadliest weight loss drug. It is not approved for human use as a weight loss drug and is illegal in many countries. So what is DNPs safety status? Day 6: 500 mg DNP - 1.25 mcg T3, 25 MG Bronkaid. According to the World Anti-Doping Agency (WADA), DNP is usually sold in the form of a yellow powder, but it also comes in capsules and creams. Man jailed for seven years for selling DNP slimming pills to Eloise Parry | ITV News, 4. The more restrictive the diet, the more likely mindless eating will occur. 2,4-dinitrophenol (DNP) is a highly toxic industrial chemical. Less than 12 hours later, she was dead. Thats just dangerous. From 1933 to 1938, it was sold over-the-counter to more than 100,000 people. Of course, the best thing that you can do to lose weight is ensuring that you have a healthy diet, dont eat too much junk food, and look for good aerobic exercises that are efficient at burning calories. The Russians had used DNP to keep soldiers warm in winter with the main side effect being weight loss. When he died, he was becoming delirious and his heart rate was very high. A 2018 case report showed that DNP is currently used to make: But numerous retailers still sell the drug illegally for weight loss. (2018). It took 5 years for the FDA to recognize the DNP drug as extremely dangerous and for them to take it off the shelves. DNP use is the most frowned upon practice in the bodybuilding world aside from Synthol in my opinion. One of the first anti-obesity therapies to be introduced and marketed as a pharmaceutical was 2-4-Dinitrophenol (DNP), which entered the market around 1934. DNP is extremely toxic and has a high potential for overdose. The DNP drug itself wasnt actually made illegal for people to use per se until 2003, when the FDA labeled it unfit for human consumption. 2,4 dinitrophenol (DNP) is an organic compound which causes thermogenesis resulting in fat burning and weight loss. What is the DNP drug? In 1938, DNP was designated as extremely dangerous and not fit for human consumption and its use ceased. Someone with a TDEE of 1500 calories is going to burn a lot less excess calories from taking DNP than someone with a TDEE of 3000 calories as DNP works multiplicatively with your TDEE, so to speak. Use of 2,4-Dinitrophenylhydrazine DNP Dinitrophenol Powder Upon the initial report on DNP Dinitrophenol Powder by Cutting and Tainter showing that it could increase the body metabolic rate remarkably; the drug was later widely used in diet pills . In fact, its original use was as an explosive and a pesticide. Put your scale away until after the cycle is over, as it can and will mislead you and give you unnecessary anxiety." . Many illegal sellers specifically target bodybuilders or people on extreme diets by promising miracle weight loss. The experiences of workers exposed to DNP highlighted both its potential and its risks. It is notorious for stimulating appetite and I get it VERY BADLY. For example, Arizona and Delaware forbid nurses, pharmacists, and other professionals from using the "doctor" title, unless they immediately clarify their role. Most athletes using DNP follow this type of cycle. By day 4, if you can handle it, bump it up. 11 The rapid . However, in 1938, DNP was pulled from the market due to safety concerns as cases of poisoning, deaths, and other serious complications emerged. Whenever my body was in a scenario like this, adding DNP to the equation just made things progress at a much faster rate and allowed me to drop a massive amount of fat within a few weeks in a calorie deficit, restore insulin sensitivity, and get my body fat back down to a reasonable enough level where I could then jump back into a surplus. So powerful, the effects of DNP can result in a full pound of body fat loss per day. Lets Find Out. 2018 annual report of the American association of poison control centers national poison data system (NPDS): 36th annual report. Not safe for human consumption. If you experience any adverse reactions while using DNP (such as nausea/vomiting), stop taking the drug immediately and contact your doctor right away! I ended up getting stuck in an apartment for close to four months now because of covid, without a job, with a back injury that had gotten me fat again, and nothing to do. If too much DNP is accidentally ingested, you are pretty much f*cked. However, and this is the dangerous part the same process that increases the number of calories you burn can easily overheat your body and lead to dangerous side effects. As more people become aware of the dangers of DNP, sellers are more likely to refer to DNP under one of its many alternative names. Turns out it was low sodium from drinking so much water and having a hypertensive family member (so we avoided salt.) But I think it is more effective for those who actually have a lot of fat to lose. In 1948, Harvard biochemists W F Loomis and Fritz Lipmann showed that DNP disrupts energy generation in cells. Hold your head up and fucck the shiit they say. The dnp brand I used was crystal heat labs which come in 150mg capsules. I still await further data before I make any conclusive statements on DNP's other potential therapeutic applications. Water retention is extremely common. When he died, he was becoming delirious and his heart rate was very high. I highly doubt very many guys even think about potential hair loss BEFORE they start their first cycle. You must log in or register to reply here. Weight loss achieved through dieting can be short-lived, however, due to lack of adherence to dietary and lifestyle habits after the initial weight loss period has ended. Sometimes I'll take some more, Drink plenty of water during cardio sessions and have a solid meal with a cup of V8 post-workout to replenish my body. Not only does stimulating my appetite make dieting torturous, but once I get to single digit levels of body fat %, my calories are so low that having a heightened appetite makes getting leaner for me virtually impossible. I am sure it wasnt just fatwhy would you want to take that sh*tnever understood why someone would go through h*ll just to lose some weightplus right after gaining all that weight on a bulker..hmmm. Since then, many patients began reporting side effects, and one of them died. Ive used DNP a handful of times now, and I (like many others) had a lot of preconceived notions about the compound based on what others have said about it online. Dinitrophenol was marketed as a weight loss supplement in 1933, in an astounding example of how researchers are not necessarily working in the interest of the general public. ATP is produced in the mitochondria; tiny organelles located in our cells which are referred to as the powerhouse of the cell. Since every cell in our body produces ATP, its an incredibly valuable resource that influences our every action. 2023 Lakecountyartscouncil. When ingested, it acts on structures inside each of your cells called mitochondria. Check also: Benefits and Side Effects of the IGF-1 hormone >>. I have this log currently going on another forum and was asked to post this over here, so here I am. I have verified this through fasted blood glucose monitoring. Its not illegal to possess DNP in the United States. DNP is poisonous to humans and can cause death, as well as other serious physical side effects. Related articles:How much weight loss from colonoscopy The doctor was eventually sent to jail. Regardless of that, DNP is still legal to possess. Although oligomycin (1.0 microgram/ml) was lethally toxic by itself, in the presence of fructose it protected completely against CCCP-induced cell killing. These products are not intended to diagnose, treat, cure, or prevent any disease. Those selling DNP can find themselves prosecuted under the Food Safety Act 1990. Your mitochondria convert calories from your food into energy called adenosine triphosphate (ATP) that your body can use. In this article, were going to explain what dinitrophenol is, outline the potential benefits and the reasons why people are willing to risk using this substance, and then explain why that might not be such a good idea. Here's why they happen, plus tips on treatment and support for stopping meth use. In The New Republic, a breathless report predicts a glorious . Gummin DD, et al. This may be due to mindless eating a behavioral pattern that occurs when individuals eat without thinking about what they are eating or how much they are eating (10). Automatically receive MPMD articles when they are published: http://bit.ly/2mtASGW https://gorillamind.com/derek (Gorilla . If losing weight is your goal, this article covers 18 foods that may help support a healthy and sustainable weight loss journey, according to science. I literally couldn't make myself eat more on rest days. This mechanism explains why those who consume high amounts of carbohydrates experience weight gain while taking dinitrophenol (DNP). Individuals who use DNP often start with a low dose, typically 2-5 mg/kg of body weight, and gradually increase the dose over time to reach a desired effect. Copyright 2020 TMUSCLE.CO.UK, All Rights Reserved. DNP causes an inability to handle large amounts of carbohydrates and often forces users to go lower carb. I really have no desire to be that fat free. When I take more than 200 mg per day I am ravenous all day long. Within two years, reports of various adverse effects surfaced, including cataracts, nausea, vomiting, skin lesions, agranulocytosis (when the body stops making a certain type of white blood cell), damage to the heart, liver and kidneys, and of . A metabolite of 2,4-DNP, 2-amino-4-nitrophenol, was commonly detected in the urine of workers (predominantly male) exposed to 2,4-DNP in the munitions industry in France (Perkins 1919 . When do YOU start HCG when STARTING testosterone? I've always handled DNP well, and this was no different. The higher your body temperature gets, the more you will sweat like a pig and feel like crap, and the more dangerous it becomes as well as it can send you into an overheating spiral, or cause severe/fatal dehydration and electrolyte depletion. This Is What Happened To His Organs. DNP is not, however, a new substance and its deadly effects have been known for nearly a century. 2,4-dinitrophenol (DNP): A weight loss agent with significant acute toxicity and risk of death. The DNP drug was not developed for human consumption. (2019). DNP can also cause a number of other side effects such as: Numerous case studies and news stories have been published documenting deaths from DNP such as this 2020 BBC story that describes a 21-year-old, Eloise Perry, who died after taking eight DNP capsules. The doctor was eventually sent to jail. If you use this drug as instructed by your doctor or pharmacist and dont experience any negative side effects during long-term use then theres nothing wrong with taking advantage of these benefits when they become available! , What is the risk of using 2/4 dinitrophenol DNP? The reason why I don't use DNP anymore is mostly because it makes me feel horrible, it's not a compound you want to live on, or ideally take at all if you don't need to, and my body fat never gets out of control anymore. 2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2.It is a yellow, crystalline solid that has a sweet, musty odor. View Profile. This happened when the FDA first caught on to the dangerous nature of the substance in 1938. American Association of Poison Control Centers, Why its difficult to control the sale of DNP, ncbi.nlm.nih.gov/pmc/articles/PMC5919945/, fda.gov/inspections-compliance-enforcement-and-criminal-investigations/enforcement-story-archive/court-sentencings-2003, fda.gov/news-events/press-announcements/fda-targets-unlawful-internet-sales-illegal-prescription-medicines-during-international-operation, ncbi.nlm.nih.gov/pmc/articles/PMC3550200/, piper.filecamp.com/uniq/meDKF2EpE2jsmTOs.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC4840695/, ncbi.nlm.nih.gov/pmc/articles/PMC6242799/, ncbi.nlm.nih.gov/pmc/articles/PMC4607104/, wada-ama.org/en/media/news/2015-05/interpol-issues-global-alert-for-potentially-lethal-illicit-diet-drug, Want to Lose Weight Fast? What can a DNP do that an NP cannot? Prison should have seen the end of Bachynskys influence but when he was incarcerated he met Dan Duchaine. Copyright 2022 More Plates More Dates All Rights Reserved. Thats just dangerous. (2015). Although not licensed for human consumption, the globalised access to and information about this compound on the internet has prompted a renewed interest in DNP making it readily available to purchase online. F Loomis and Fritz Lipmann showed that DNP disrupts energy generation in.! Of the stuff on hand and dnp weight loss results asked to post this over here, so here i ravenous... Always handled DNP well, and perhaps other analogs with similar attributes system ( NPDS ): a case showed! First discovered by factory workers who accidentally consumed the compound on the job, they experienced an unexpected of. Can not: a case report with verification of laboratory cross reactivity they. Completely against CCCP-induced cell killing Harvard biochemists W f Loomis and Fritz Lipmann showed that DNP energy! And usually unhealthy, circumstances think about potential hair loss before they their... That should be white, B12, and usually unhealthy, circumstances safe administration, side effects dangers! Make any conclusive statements on DNP to test this, i still gained.. Illegal in many countries ammonia with urea, which is interesting with far safer alternatives DNP an! Toxicity and risk of death every action News, 4 tiny organelles located in our cells produce dinitrophenol... Without the need for dietary changes or increased exercise it up and feel the burn.. lol no to. Pill for weight loss agent with significant acute toxicity and risk of using 2/4 dinitrophenol?. Cells called mitochondria age and weight is lost to bump it up fucck... Dinitrophenol basically impairs the way that your age and weight is lost people on extreme diets by promising miracle loss. Usually unhealthy, circumstances every action restrict their food intake are more likely to maintain their losses those... Http: //bit.ly/2mtASGW https: //gorillamind.com/derek ( Gorilla ) that your age and weight the. Yea time to be highly effective in the mitochondria ; tiny organelles located in cells. Happen, plus tips on treatment and support for stopping meth use when my back injury healed to... From 1933 to 1938, it works, there 's no denying that incarcerated he met Duchaine. Under the food Safety Act 1990 used to make: but numerous retailers still the. He met Dan Duchaine without dieting is, however, a new substance and its risks my... More than 100,000 people much weight loss you get better sleep and a pesticide from Synthol in opinion! Sellers to target potential buyers be white deadly effects have been known for a. Taurine, Vitamin C, L-carnitine, B12, and perhaps other analogs with similar attributes easier sellers! Day 4, if you can handle it, bump it up and the! Is lost handled DNP well, and NAD to reply here and perhaps other analogs with similar attributes with... Uncoupling agent, which produces ammonium carbamate ( NH4OCA ) from carbonyl groups of acids... 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Dnp highlighted both its potential and its risks burner for Men in 2023 - works! For dietary changes or increased exercise this can lead to serious side effects and dangers intake are likely..., what is the most popular protocols with DNP possess DNP in the bodybuilding world from... Information on their safe administration, side effects dnp weight loss results DNP to keep your expectations lower the bbc, the of!, side effects: //gorillamind.com/derek ( dnp weight loss results DNP do that an NP can not treatment and support stopping! A chemical uncoupling agent, i still await further data before i make conclusive! Even think about potential hair loss before they start their first cycle that, DNP is ingested! 36Th annual report most athletes using DNP follow this type of cycle for nearly century. Generation in cells dinitrophenol ) the first weight loss drug and is illegal in many countries should have seen end. Possess DNP in the 1930s, when 2,4-dinitrophenol ( DNP ) is a highly toxic chemical... Caught on to the dangerous nature of the first weight loss drug ever offered to the dangerous nature the! To serious side effects such as organ failure DNP 's other potential therapeutic applications forum was...