We propose that during nuclear reassembly LEM2 condenses into a liquid-like phase and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin and the spindle. Discovering how new proteins work could lead to lifesaving therapies for cancer or new painkillers with less danger of addiction. 2021 Jul 21;10:e59999. Exactly how Stentor learns without a brain is a question that Deepa Rajan, a graduate student in UC San Franciscos Tetrad Graduate Program, is trying to answer. Deepa Rajan presents her winning talk, Learning Without a Brain. Watch the full 2023 Grad Slam. Journal of Structural Biology, 2015 Nov;192(2):174-8. : 10.1016/j.jsb.2015.09.003. Be Bold, Little Mouse: Finding Courage in the Brain, Mashel Fatema Saifuddin (Tetrad Program) In a 2022 interview with The Times, Adam, 53, explained that he and his wife Sulina had both been unwell, alongside their 15-year-old daughter Amber-Lily. Her talk on this work recently won the top prize in the 2023 UCSF Grad Slam. Assistant Professor, Biochemistry and Biophysics. New Website Checklist; Quiz: Do I Need A Website? Theres a precise point where you go from seeing rather useless blobs to being able to directly interpret a molecules structure. Adam Frost UCSF, US Alexandr Noy LLNL, US Alicia Alonso University of the Basque Country, ES Anjon Audhya University of Wisconsin-Madison, US Atul Parikh UC Davis, US Avital Rodal Brandeis University, US Dora Tang MPI-CBG, DE Durba Sengupta NCL, IN German Rivas CIB-CSIC, ES Harry Low Imperial College London, UK Ling-Gang Wu The star usually tends to keep his private life out of the. 4/17/2023 11:23 AM. Is there additional information on UCSF websites that would be helpful to you? Application significantly improves Thon ring quality and 3D reconstruction resolution.NOTE: This software may only be downloaded and used for free by academic and/or non-profit users. All Rights Reserved.Department of Molecular Biology, Assistant Professor, Biochemistry and Biophysics, Free and open to the university community and the public, Fred Hughson, Department of Molecular Biology, Genetics and Molecular Biology Training Grant, Genome Editing Shared Resource (Rutgers-CINJ), Glenn Center For Quantitative Aging Research, Lewis-Sigler Institute for Integrative Genomics. UCSF Site Builder; Custom-Built Sites; Website Hosting; . The reformation of sealed nuclei requires ESCRTs (endosomal sorting complexes required for transport) and LEM2, a transmembrane ESCRT adaptor2-4. Click here for the MotionCor2 License Agreement and Download page. UCSF graduate programs were among the first in the country to break down traditional barriers between departments and disciplines, and interdisciplinary thinking permeates the program curriculum and faculty. 600 16th St., S101. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Hit 'Like' on our Facebook page, follow us on Instagram, join the conversation on Twitter and listen to our latest podcast . Proceedings of the National Academy of Sciences 114 (11), E2166-E2175, New articles related to this author's research, Department of Biochemistry, University of Geneva, Professor of Molecular Biosciences, Northwestern University, University of Utah, University of California San Francisco, University of California San Francisco; Whitehead Institute for Biomedical Research, Professor of Oncological Sciences, University of Utah, Department of Oncological Sciences, University of Utah, Postdoc in Wyss-Coray and Bertozzi labs at Stanford University, Professor of Biochemistry and Molecular Genetics, University of Virginia, University of Pittsburgh, Dept. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI. DOI: 10.1101/2021.12.03.471181. S412C 600 16th. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. yifan.cheng@ucsf.edu +1 415 514-9708 We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). Housed in Genentech Hall, the goal of this state-of-the-art facility is to develop, in collaboration with the optical group, an integrated approach for imaging, ranging from atomic resolution to whole cells, with emphasis on linking structural and dynamics information with biological functions. San Francisco, CA. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Her hypothesis is that in people with neurodevelopmental disorders, microglia are struggling to find the right synapses to prune. Participating in Grad Slam has been an amazing opportunity to exercise and grow my communication skills, Teter said. The spatial movement of the sample as a result of stage tilting can be predicted based upon previously . Email. This years event was held in person at Genentech Hall at Mission Bay and streamed live on YouTube. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. She identified a signal that microglia use to find synapses and showed that neurodevelopmental disorders can hijack this signal. The system can't perform the operation now. The W.M. Speaker. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. UCSF Profiles is UCSF's version of the ground-breaking, open source "Profiles Research Networking Software" that was developed under the supervision of Griffin M Weber, MD, PhD, with support from Grant Number 1 UL1 RR025758-01 to Harvard Catalyst: The Harvard Clinical and Translational Science Center from the National Center for Research Resources and support from Harvard . The recent work with cryo-EM has been so successful that many researchers at UCSF have begun clamoring for a share of the limited microscopy time available on shared scopes. Dephosphorylation in nuclear reassembly after mitosis. Noncontact dipole effects on channel permeation. P50 GM082545/GM/NIGMS NIH HHS/United States, R01 GM131052/GM/NIGMS NIH HHS/United States, P50 AI150464/AI/NIAID NIH HHS/United States, P30 CA042014/CA/NCI NIH HHS/United States, DP2 GM110772/GM/NIGMS NIH HHS/United States, eScholarship, California Digital Library, University of California, Ungricht R & Kutay U Mechanisms and functions of nuclear envelope remodelling. Unauthorized use of these marks is strictly prohibited. Academic Information. Biology, The BAR domain superfamily: membrane-molding macromolecules, Structural basis of membrane invagination by F-BAR domains, GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission, A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress, Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms, Membrane fission by dynamin: what we know and what we need to know, The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis, An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike, Structural basis of membrane bending by the N-BAR protein endophilin, Structure and membrane remodeling activity of ESCRT-III helical polymers, Structural basis of mitochondrial receptor binding and constriction by DRP1, The docking protein FRS2 controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors, Structures, functions, and dynamics of ESCRT-III/Vps4 membrane remodeling and fission complexes, Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission, Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens, Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions, The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins, A structural biology community assessment of AlphaFold2 applications, LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. 4 |. Adam Frost studies the molecular machines that are too fragile to purify, too large or flexible to crystallize, or are dependent on lipids that cannot be replaced by detergent micelles. . 5 |. Adam Frost (UCSF) Butler Seminar Series. Want more information and inspiration from The English Home? # Contributed equally. Adam Frost. 2022 Nov 15;132(22):e158897. Until recently, such a feat would have been considered impossible, but in the past five years, such breakthroughs have become almost commonplace here, part of a resolution revolution being led by UCSF researchers. In order to derive unique insights into cell biology and human disease, we integrate atomic structure determination by cryo-EM with genetics, biochemistry, and diverse imaging techniques. . Structural and functional studies of membrane remodeling machines. Extended Data Fig. Homology modeling, Extended Data Fig. 2 |. Cite publication: Shawn Q. Zheng, Eugene Palovcak, Jean-Paul Armache, Yifan Cheng and David A. Agard (2016) Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy, Nature Methods, submitted. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. Proc Natl Acad Sci U S A. Agard sees the cryo-EM revolution as closely synergistic to other burgeoning efforts on campus to completely map out the biology of disease, such as the work of Nevan Krogan, PhD, the director of UCSFs Quantitative Biosciences Institute, who is mapping the common networks of genes and proteins that drive diseases ranging from cancer to HIV to schizophrenia; and the work of Brian Shoichet, PhD, whose lab in UCSFs School of Pharmacy uses protein structures to computationally design custom drugs that fit like lock and key into target proteins. Olivia Teter, a graduate student in the Bioengineering Program at UCSF, won third prize and received $1,000 for her talk on Nipping Neurodevelopmental Disorders in the Bud. She used a metaphor to explain her research, suggesting that immune cells called microglia act like gardeners that prune synapses in the brain. doi: 10.1083/jcb.202201024. sharing sensitive information, make sure youre on a federal WATCH: Gardeners' World presenter Adam Frost gives a tour of his stuninng garden. UCSF EMCore - high-resolution structures & high-throughput - By using image-shift data collection, we've achieved physical Nyqvist frequency using our high magnification data collection settings and beyond (> 150%) physical Nyqvist . UCSF Tomography It is used to collect single-axis tilt series on electron transmission microscopes. 2020 Jun;64:25-33. doi: 10.1016/j.ceb.2020.01.011. Bookshelf Structural basis of membrane deformation by the ESCRT-III family of proteins (107.4). J Clin Invest. University of California, San Francisco. eIF2B conformation and assembly state regulates the integrated stress response. Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. BioArxiv:http://biorxiv.org/content/early/2016/07/04/061960, More details please refer to UCSF Macromolecular Structure Group - Software, 2023 The Regents of the University of California, http://biorxiv.org/content/early/2016/07/04/061960, UCSF Macromolecular Structure Group - Software, Nature Methods, 10, 584-590. A native of Utah, Adam Frost received his undergraduate degree in biochemistry at Brigham Young University. Gardeners' World presenter Adam Frost has been a regular face on the BBC for many years now, having presented the popular horticultural show since 2016 as well as the channel's coverage of the RHS . He then received a masters in physics from UCLA in 2004, before moving to the University of . Rajan was one of 10 graduate student finalists competing in this years UCSF Grad Slam held on April 4, in which students presented their research in three minutes or less in terms easily understood by a general audience. Livestream Information Zoom February 16, 2021 (Tuesday) 12:00pm Meeting ID: 96151442305. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. 17 Oct 2022. This software was implemented based upon a novel approach in which the Compustage tilting is modeled as geometric rotation. Another leading cryo-EM researcher at UCSF, Adam Frost, MD, PhD, who joined the university as an assistant professor in 2014 to take advantage of the power of this new technology, has been leading efforts to use cryo-EM to determine how new classes of drugs bind to their target proteins at the atomic level. February 22, 2023. 8 Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. Nuclear envelope budding and its cellular functions. See more. -, Gu M et al. Welcome to the Frost lab.We are a part of Altos Labs and work at the San Francisco Bay Area Institute of Science.We are affiliated with the Chan Zuckerberg Biohub, the University of Utah, and the University of California, San Francisco. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Ahead of the world-famous gardening show and to celebrate the release of his new book, The Creative Gardener, we sit down with Adam over a cup of tea to talk all things dogs, pet-friendly planting and his . BAF is required for emerin assembly into the reforming nuclear envelope. Search. Adam.Staffaroni@ucsf.edu. Contribute to AdamFrostLab-UCSF/website development by creating an account on GitHub. Electron Cryo-Microscopy; Structural Biology; Membrane Biology; Cell . Cancer Cant Breathe (or Grow) with No Aire, Evelyn Hernandez (Tetrad Program) 2022 Oct 4;10:1012768. doi: 10.3389/fcell.2022.1012768. Read More . Frost Dr. Adam Frost, UCSF, will deliver a virtual seminar on Tuesday February 16th, 2021. Lunch @UCSF with Adam Frost - Cryo-EM comes of age. 7:45 pm - 8:00 pm: Jeanne Stachowiak (The University of Texas at Austin, United States) "Flexible Protein Networks Organize and Remodel Membranes During Clathrin-Mediated Endocytosis" Activated CHMP7 forms polymeric rings via its ESCRT-III domain, exposing, Extended Data Fig. The live event final judges were Abby Buchwalter, PhD, assistant professor at the Cardiovascular Research Institute, Dan Lowenstein, MD, the Robert B. and Ellinor Aird Professor of Neurology at UCSF; Florie Mar, PhD, global medical science director for medical affairs at Genentech and founder and president of Youreka Science; Elise Marsan, PhD, a postdoc and first prize winner of Postdoc Slam 2022; and Carla Washington, PhD, Graduate Division Alumni Association president at UCSF. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Endosis and exosis: new names for fusion and budding. Associate Professor. 7 |. The W.M. 5 |. of Biochemistry & Biophysics Box 2240, Room: San Francisco, UT 94158. March 15, 2023. Academic Office Information. Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance. Sulina, 46, was hospitalised and . Languages spoken: The 10 finalists were selected by a panel of screening judges who reviewed more than 30 initial video entries. We are part of the Department of Bioengineering and Therapeutic Sciences, the Macromolecular Structure Group, and the California Institute of Quantitative Biosciences (QB3). of Comp. In addition to the judges award, the in-person and remote audiences voted for Rajan to receive the Peoples Choice Award. Keuenhof KS, Kohler V, Broeskamp F, Panagaki D, Speese SD, Bttner S, Hg JL. Nucleus. 2023 The Regents of the University of California. Facility Access & Rules; Scheduling & iLab; FEI T12 TEM; FEI T20 TEM; Talos Arctica Cryo-TEM; Glacios Cryo-TEM; Aquilos 2 Cryo-FIB; Titan Krios Cryo-TEM; Documents. UCSF researcher Adam Frost takes you on a tour from his home in Mill Valley, CA, to his lab at UCSF's Mission Bay campus in beautiful San Francisco. The Omicron Effect: Can We Predict the Next Viral Killer. But in people with neurodevelopmental disorders, microglia do either too much or too little pruning. Protein folding in vivo, protein sorting, and macromolecule dynamics. It also made possible discoveries in Agards lab about proteins that help other proteins maintain their proper shape, a process that has major implications for cancer and diseases such as Alzheimers disease that are characterized by misshapen proteins. Frost and Cheng have also been using cryo-EM to understand how signaling proteins on the surfaces of cells key targets for pharmaceuticals from pain killers to cancer therapies are influenced by the cell membranes in which they float and how proteins can bend and shape the membranes. PMID: 26370395, Journal of Structural Biology, advanced publication online June. The site is secure. . Structural Cell Biology Biochemistry Membrane Biology Proteostasis Electron Micoscopy. 3 |. Structural basis of membrane invagination by F-BAR domains. But at UCSF, the culture nurtures us to do things that everybody else thinks are impossible.. The LEM motif of LEM2 binds BAF, conferring on LEM2 an affinity for chromatin5,6, while an adjacent low-complexity domain (LCD) promotes LEM2 phase separation. LEM2 wets the surface of microtubules with a liquid-like coat. Another leading cryo-EM researcher at UCSF, Adam Frost, MD, PhD, who joined the university as an assistant professor in 2014 to take advantage of the power of this new technology, has been leading efforts to use cryo-EM to determine how new classes of drugs bind to their target proteins at the atomic level. Careers. FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. In Eukarya, stalled translation induces 40S dissociation and recruitment of the ribosome quality control complex (RQC) to the 60S subunit, which mediates nascent chain degradation. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Jaysn Davidson, a graduate student in the Pharmaceutical Sciences and Pharmacogenomics Program at UCSF, took second prize and received $2,000 for his talk on Improving Health Equity Bit by Bit. Davidson described his research on how analyzing social determinants of health could help make health care more equitable. Regulation of transcription and translation. Contact us, 2023 The Trustees of Princeton University. Otherwise, it won't blot); Click the checkbox of "humidifier off during process" and "skip grid transfer". Biochemistry - Adjunct Assistant Professor, Copyright 2023 University of Utah Health, Biochemistry - Adjunct Assistant Professor, UCSF - Professor Adam Frost - Dept. 5F- and 6F-Trp gramicidin channel currents. Fortunately, with the acquisition earlier this year of new fully automated cryo-electron microscopes, including a $5 million state-of-the-art Titan Krios system funded by the Howard Hughes Medical Institute, a $6 million Titan Krios funded by an anonymous donor for the UCSF Institute of Neurodegenerative Disease part of the UCSF Weill Institute for Neurosciences and a $3 million Arctica system funded by the National Institutes of Health and UCSF, more and more researchers across the University and the Bay Area will be able to take their research to the next level. His big break came when he worked with Geoff Hamilton . Adam Frost is a garden designer by trade He shares four children with his wife, Sulina, and the pair are thought to have been married a number of years, however, it is not known when they tied. He is most known for his achievements at the Chelsea Flower Show and for his role as a presenter on the BBC program Gardeners' World. at Yale School of Medicine and his Ph.D. at Yale University before completing a postdoctoral fellowship at UCSF with Jonathan Weissman. a***@ucsf.edu. University of California San Francisco. She uses a device in a lab to tap Stentors over and over and analyze how they expand or contract in reaction. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Research in the lab is focused on discovering the fundamental principles of macromolecular structure and dynamics. 29 October 2017. Rajan will go on to represent UCSF at the UC system-wide Grad Slam on May 5. LEM2 promotes early nuclear compartmentalization via cooperation between its LCD, Extended Data Fig. Try again later. Tel: (415) 476-9819. adam@abatelab.org. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. This is beginning to have a huge impact all around campus, but now we need to scale it up to lower barriers and speed the transition from images to therapies., 2023 The Regents of The University of California, University Development & Alumni Relations, Langley Porter Psychiatric Hospital and Clinics, UCSFs Cryo-Electron Microscopy Advancements Bring Atomic-Level Life into Clearer View, Theres a More Humane Way to Monitor Crohns and Colitis Patients, $147M Grant Will Address Imbalances in Alzheimers Study, restore memory failure in patients with traumatic brain injury, targeted by a new generation of pharmaceuticals, UCSF Institute of Neurodegenerative Disease, The Resolution Revolution: Building a Better Microscope to See at the Atomic Level. UCSF News. The BAR domain superfamily: membrane-molding macromolecules. eCollection 2022. 6 |. Our research is focused on elucidating the mechanism of Hsp90 chaperone function and its role in human disease, microtubule nucleation & centrosome structure, and the structure and cell biology of phage-encoded tubulins. Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M, Tsai K, Stojkovic V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG, Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander Czuchra, Leonora Martnez-Nez, Lillian Kenner, Adam Frost, Patrick Brennwald, Michael Schoof, Morgane Boone, Lan Wang, Rosalie Lawrence, Adam Frost, Peter Walter, Sun M, Azumaya C, Tse E, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA, Miller-Vedam LE, Bruning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS, Ming Sun, Caleigh Azumaya, Eric Tse, Daniel Southworth, Kliment Verba, Adam Frost, Yifan Cheng, David Agard, Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK, von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A, Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR, Iwasa JH, Vershinin MD, Sundquist WI, Frost A, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander B Czuchra, Lillian Kenner, Leonora Martnez-Nez, Adam Frost, Patrick Brennwald, Stojkovic V, Myasnikov AG, Young ID, Frost A, Fraser JS, Fujimori DG, Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P, Mary Munson, Dante Lepore, Michael Feyder, Guendalina Rossi, Alexander B. Czuchra, Lillian Kenner, Leonora Martinez-Nunez, Jacqueline M. Forson, Adam Frost, Patrick Brennwald, Henry C. Nguyen, Nathaniel Talledge, John McCullough, Abhimanyu Sharma, Frank R. Moss, Janet Iwasa, Michael Vershinin, Wesley I. Sundquist, Adam Frost, Romanov V, McCullough J, Gale BK, Frost A, Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A, Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N, Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK, Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A, Zurita Rendn O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J, Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS, Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P, Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A, Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS, Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE, Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A, Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S, Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ, Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M, McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A, John McCullough, Leremy Colf, Marissa Saunders, Matthew Lalonde, Gaelle Mercenne, Wesley Sundquist, Adam Frost, Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A, Adam Frost, Wes Sundquist, John McCullough, Marissa Saunders, Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM, Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS, Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS, Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM, Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F, Adam Frost, Carsten Mim, Rushika Perera, Krasimir Spasov, Edward Egelman, Pietro De Camilli, Vinzenz M Unger, Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM, Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD, Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J, 2023 The Regents of the University of California, Critical reviews in biochemistry and molecular biology, Annual review of cell and developmental biology, Proceedings of the National Academy of Sciences of the United States of America. 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