She is healing and has no new rashes or sores. Never again!! Nothing they can do for her she said. These signs usually resolve without treatment. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. No appetite, not like Charlie. We just brought him home from hospital today. My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. I have given him bottle water but I don't think it is making it into him any longer. She would constantly twirl in left circles. KingsGuard2603 2 yr. ago. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. But anyways - the other night , his feet collapsed from under him & he fainted . Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. All Rights Reserved. In a third field safety and effectiveness study, Simparica TRIO was administered to 120 dogs with roundworms. She was being seen by her regular vet and was put on antibiotics. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. Are their enough people to file a class action suit? Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. I dont know what to do to get this out of their system?? I used to use revolution but they dont cover ticks as well. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. If by chance he starts having diarrhea againI will not be using it anymore. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. Im so upset with myself. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. Side effects with Simparica are not common. So sad as he was once a happy healthy dog with no prior health issues. It is really eye-opening to see everyone's experiences. Some common side effects of various flea, tick, and worm preventatives include: Vomiting or diarrhea; Loss of appetite; Lethargy Did your dog pass away? They got him to eat a little the next morning and sent him home. Im convinced it was caused by this drug. Its crazy to think they dont recover and can die in a few months. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I returned to vet next day with him and was advised he was ok. Hi, Im having similar issues. The vet and company are in consultation. First time for this adverse reaction. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. I put water with electrolytes by his cage & food . We are currently going through this with our nine year old dachshund. Is your dog still having tremors? I am not giving him his dose this month and seeing what happens. Since the weather was turning cold, I stopped giving her the Simparica until spring. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. My dog is still having tremors 5 months after taking Simparica. Never again are my dogs getting oral medication for fleas & ticks. I finally got him to eat some chicken and he threw that up 2 hours later. Was at the doctors 2 days ago for an emergency appointment. He is a 89 lbs 5 y/o pitbull who has never had any issues before. The vet does not feel it is due to Simparica but i think it could be. Never happened before. The issues started within 24 hours of the dose and continue. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. They were taking Simperica for flea/tick and Heartguard to prevent heart worms. This behavior is so inconsistent and confusing. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. I am hopeful he will make it through the next few weeks. Somedays he will have 2 and then he will go for a couple days without having any issues. Did you go to the vets or not? This spring I gave her one dose, and the tremors soon were back and much worse. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. She had the treatment yesterday and seemed ok. He had a serious skin issue a few months back and it was blamed on fleas. No simparica for them either! Then things got progressively worse. He licks his lips all the time? Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog . how long do simparica trio side effects last Author: Published on: in what way did this ruling produce a fundamental change in the united states 21 septiembre, 2020 Published in: hicks family genealogy My 11 year old mini Aussie has been taking Simparica 1.5 years. DO NOT give this poison to your pets. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. Very dissapointed with my vet for not informing me of the risk this has on my dog. Thank you for this. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. My dog is currently in an emergency hospital in Chicago with my daughter. He is just laying in his crate . It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. My 3 other poodles unaffected. 24 hours later she had another one. Lost all appetite. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. I hope and pray for no long term affects. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Does anybody know how long this will last? Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). I am also going to contact the vet who gave it to me and tell him all this stuff. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. She also started with ear infections. No more of this junk for my pups! You don't think I'm going to continue with this poison. For 5 years I have resisted my veterinarians suggestions for oral flea meds. When he lays in the sun you can see the bumps under his skin. Oh Lord, back to finding another vet. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. Thanks Michelle! She sensed his anxiety and uneasiness as him having sight issues. She is still eating but she is drinking more water. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. As with any medication, there is a potential for side effects when using alternatives to Simparica Trio. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. this link is to an external site that may or may not meet accessibility guidelines. I don't want another animal harmed by this stuff, one animal is one to many. I have been giving my lab puppy (6 months old now) Simparica Trio since October. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. Seizures. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. I'll continue to watch her. Once she is completely healed I am putting her back on those. I would not recommend giving Simparica to your pets!!!!! Anyway, he prescribed him pain relief for 7 days. She started it on 7/22. He had no events and seemed to be a healthy and happy animal. It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. He had full wellness exam three ago and was in perfect shape. I just almost had a similar incident with my 16wk cavapoo. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. Some of the most common side effects of Simparica include vomiting, diarrhea, lethargy, (Read: Why is my poop black liquid?) Went to a different vet, within minutes he found a large mass on my Poms abdomen. The company will not cover any products purchased through sites like Chewy or 1-800-Pet-Meds because they cannot be tracked to ensure they're legitimate and properly stored/handled (and due to the company's stance on product diversion). I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. Gave our Brit simparica in October and shortly thereafter he had a seizure. 24 hours after, we noticed diarrhea. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. We were so upset - I vowed to never use oral flea treatment again. They gave him a strong shot of prednisone that was good for 2 days . He protected our livestock from coyotes for many years and I took good care of him. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. Getting him to go out was nearly impossible. He is also running a fever so is not out of the woods. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. MONEY!!. . And she keeps whining. He is not the same puppy prior to two days ago! Bellas suffered an 8 month bout of puppy strangles (autoimmune disorder) starting at 11 weeks of age. 10 days after taking Simparica, she started having muscle tremors. He was a normal dog before the medicine Simpatico Trio . It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. All oral tick meds are a risk. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! The very next day he had diarrhea, and had it for 6 days. I'm so sorry. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. old . Vet did all kinds of tests but said it couldnt be simparica. What Are The Side Effects Of Simparica Trio For Dogs? We are now at about 45 days since last simparica and he is back to his old self. Snores like a big dog. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. I bought chicken last night he ate some of that . like what??? Product Details: Simparica Trio Chewables for dogs. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. Took him back to the vet. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. This morning I caught him chewing the end of his tail and eating his fur. I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. If there are enough reports they may have to pull it off the market until further safety tests can be done. However, doing nothing is better than giving her the Simparica. Seizures continue and its Monday. I wouldnt have given it to her. Best of luck. I had always thought how can something so lethal to fleas an ticks be safe to ingest? Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. The cardiologist found no heart condition that would cause this. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. Im going to another vet and discontinuing simparica. They must get some kind of monetary bonus for only selling Simparica. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. The following day she got diarrhea and was extreemly quiet. How do I get this out of his system and what are you using instead? Were there any other conditions? but wasnt allowed in with him. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. I am sure simparica caused a fatal seizure in my boxer. But few people read it or think it must be a million to one problem. I will update once we have results from diagnostics. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. Any response from the company? She has been very unpredictable and snapping at people but this is improving. How long do the side effects last? Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. The following day he would not even drink water. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. What is a good replacement? I was furious with the drug and the prescriber too. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. She has been on it for 6 months. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. I just gave him heartgard and nexgard about 2 weeks with no issues. Any suggestion? He is pissing a lot and often and drinking a lot of water. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications." Did you do this yourself or let the vet? We immediately gathered her up and took her to the vet. Other possible side effects of Trifexis include itching (affecting about 4% of dogs), lethargy (2.6%), and diarrhea (2.3%). Been also very lethargic not wanting to get out of bed. We did not make the connection until today. $20.45 Trifexis Chewable Tablets for DogsRx Product Details Product Description Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. A month later, he was at doggie daycare and we picked him up and he was panting frantically. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. iI hope she will not have any other problems. Hello to everyone and I am so sorry we had to meet under these circumstances. I wish I read these side effects before my vet recommended Simparica Trio for my 12 week old Bichon. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Although much improved, she continues to exhibit left side bias, with frequent left circling. He has been on simparica since he was old enough to take it. The vet office called simparica hotline to find out if it was safe to give her another one. Any advice on the diarrhea? Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. It's been the worst 2 months. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. He looked like he was having spasms. Today shes been panting. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. He is starting to get better. Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. Over time, I spent 7k to save here but to no avail. Ticks are horrible here in Maine. just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. 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